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Synergistic Effect of Curcumin and Adriamycin on Liver Detoxification Enzymes in Hepatocellular Carcinoma-Induced Wister Strain Albino Rats.

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Muthusamy Thangavel*1, Deepalakkshmi Balakrishnan1, Saramma Mini Jacob1
» doi: 10.48047/ecb/2023.12.12.26


Although hazardous industrial chemicals as well as pollutants in the air and water are causes of hepato cancer-causing potential in the former, additives to food and fungi are the primary causes of liver damage in the latter. Hepatocarcinoma is an important issue not only in wealthy nations but also in most developing countries. In Wistar strain rats, it has been discovered that daily dietary treatment of curcumin (2 mg/ml b.wt.) plus adriamycin (20 mg/kg b.wt.) significantly lowers the incidence of cancer caused by N-nitrosodiethylamine (DEN). Researchers have discovered that curcumin as well as adriamycin treatment is effective in reducing the liver microsomal the glutathione, cytochrome b5, cytochrome p450 NADPH-cytochrome C reductase, decreased glutathione-S-transferase, and glutamyl cysteine synthetase activities to a level that is statistically significant when measured in the hyperplastic a nodule or in the surrounding. Additionally, as compared to control rats, the study's curcumin and adriamycin treatments significantly reduced the microsomal activities of cytosolic glucose-6-phosphate dehydrogenase. Curcumin and adriamycin both have the potential to be anticancer medicines by modifying the activity of the enzymes that metabolise glutathione.

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