Syncope is a medical emergency characterized by a transient reduction of blood flow to the brain, which results in momentary and reversible loss of consciousness. It is a sudden, transient loss of consciousness associated with a loss of postural tone. These occur as a result of an abrupt drop in systolic blood pressure to below 70 mm Hg or in mean arterial pressure to below 40 mm Hg, which results in a brief interruption of cerebral blood flow lasting more than 8 seconds. This article will provide a comprehensive review of understanding the evaluation of loss of consciousness, etiology, pathophysiology, and thorough management protocol of syncope