Curcumin, known as the „wonder of drug‟ is proven to be efficacious in a variety of chronic diseases including diabetes. Type 2 diabetes is more common among diabetes also known as insulin resistance or hyperglycemia. Hyperglycemia leads to formation of glycation end products which is considered as highly toxic to human body. Conventional therapy fails to treat diabetes effectively and the side effects are a major challenge. Curcumin, herbal medicine have various pharmacological activity is still used as an adjuvant and not as first-line therapeutic agent because of its poor solubility and bioavailability.