The presence of the Superficial Brachial Artery is not uncommon. Varied incidence, origin, course and termination are described in the literature. Attempts are made to co-relate with embryology and to classify this variation into different categories. The present case report describes coexisting anatomical variations in the neurovascular topography within the axillary fossa and arm. The presence of the Superficial Brachial Artery originating from the second part of the axillary artery was observed. Atypical common steam for the Anterior Circumflex Humeral Artery, Posterior Circumflex Humeral Artery and Profunda brachii was also found. The presence of SBA can cause median nerve entrapment and result in the neuropathy. Being superficial, it is vulnerable to the trauma and can be mistaken for vein in various clinical procedures. Hence variations of the brachial plexus and median nerve relationships with the axillary and brachial artery like SBA are significant to anatomists, radiologists, anaesthetists and surgeons.