Discomfort has been defined as a negative feeling which may be subjective in nature that may include an array of symptoms such as abdominal fullness, early satiety, bloating, nausea or vomiting. Present study was aimed to study clinical presentation of the patients undergoing upper Gastrointestinal endoscopy along with the frequency and distribution of findings in various age groups and genders. Material and Methods: Present study was Hospital based prospective descriptive study, conducted in patients above 13 years of age, of both gender, with uncomplicated and uninvestigated dyspepsia. Results: Out of 100 patients, there were 68 (68%) male patients, 32 (32%) female patients, most of the patients were in the age group of 41-50 years (25%) followed by the age group 31-40 years (23%). Most common abnormal endoscopic finding was gastritis 27 (54.1%) patients, followed by GERD in 14 (28.6%) of patients, Duodenitis in 4 (9.1%) patients, esophagogastritis was present in 4(9.1%) patients. Carcinoma stomach in 1 (1.4%) patients, carcinoma esophagus were noted in 8 (18.3%) patients, gastroduodenitis in 9 (16.4%) patients. Malignant lesions were seen frequently in patients aged more than 50 years. Most common component of dyspepsia was epigastric pain and discomfort, seen in 90 (90%) patients, followed by nausea and/or vomiting 78 (78%) patients, heart burn in 70 (70%) patients, food intolerance in 52 (52%) patients, indigestion in 48 (48%) patients and loss of appetite and/or weight in 35 (35%) patients. Conclusion: Upper GI endoscopy can be helpful to uncover the cause and helps to start an appropriate management. Upper GI endoscopy is an important tool in the diagnosis, follow up and treatment in upper GI disease