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ISSN 2063-5346
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Study the Exons 5 and 6 GSTP1 SNPs and Correlation with Physiological Growth Hormone and TAO-C Levels in Iraqi patients with T2DM

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Rawaa S.A. AL-Azawi1, Enas D. Neama2, Zena S.M. Al-Tamemi, Zahraa H. Kadhim
» doi: 10.31838/ecb/2023.12.3.135

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a complicated, miscellaneous, not autoimmune, and multiple gene inheritances metabolic disease condition, in which the body is not able to produce sufficient insulin and is characterized by irregular glucose homeostasis. This study aimed to evaluate the effect of Exons 5 and 6 of Glutathione S-Transferase P1 GSTP1 Ile/Val 105 (I105V) and Ala/Val 114 (A114V) SNPs and Correlation with Physiological Growth Hormone levels in Iraqi Patients with T2DM. Methods: A total number of 60 patients with T2DM and 30 subjects as control were used. The ELISA and spectrophotometer assessed GH and TAO-C levels, respectively, while GSTP1 I105V and A114V SNPs was an estimate were estimated by PCR-ARMS and restriction fragments by Alw26I.

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