Introduction: Head injury is a global issue as a result of industry and transportation development that cause a large number of accident victims. Head injury still constitutes a serious health problem nowadays. The number of incidents, level of disability and mortality rate are still high 75- 80% of the total number of head injury are mild, moderate and severe. Aim and Objectives: To study the role of Thrombocytes, ESR and serum albumin for prognosis of Head injury. Methods: Clinically diagnosed with Head injury patients and admitted to Neurosurgery department at National Institute of Medical Science & Research, Jaipur. Blood sample was taken within 24 hrs. as per protocol. Results: The severity of head injury with Glasgow coma scale (GCS). The status of the parameter compared as well as their association and role in prognosis analyzed. Conclusion: Thrombocytes, ESR and albumin can become a useful and affordable marker. Serum albumin used as prognostic biomarker in predicting outcome on patients with Head injury.