Stroke is the second leading cause of death worldwide and was responsible for an estimated 6.5 million deaths and 113 million DALYs in 2013. Stroke. Hyperuricemia has been shown to have a positive association with CV morbidity and mortality. This study helps to find the relationship between serum uric acid and Acute ischemic stroke. Methodology: It was a retrospective study conducted at the tertiary hospital Karwar Institute of Medical Sciences. Data of 100 consecutive patients suffering with Acute Ischemic Stroke was collected and 100 controls data was collected matching their age, sex, comorbidities and habits.After obtaining approval from MRD, the patients details were collected from the case sheets. General health characteristics such as age, sex, smoking status, menopausal status, alcohol consumption, and dietary habits (particularly as related to preference) were collected. CT brain report and serum uric acid levels report was collected. The outcome of hospital stay in form of referral, discharge and death was noted. Data collected was analyzed statistically using descriptive statistics and also appropriate parametric or non-parametric tests were applied Results: A total of 100 consecutive cases of Acute Ischemic stroke and 100 controls data was collected. Cases and control were matched for age, sex, habits and comorbidities. There were 62 male patients and 38 female patients each in both groups with male to female ratio of 1.6:1. Mean age of study population was 61.9(±10) years. Out of 100 cases 33 male patients were alcoholic and 43 male patients were smokers. Among cases 69% patients had Hypertension, 38% had Diabetes and 36% patients had dyslipidemia. Mean Uric Acid level among controls was 5.45 mg/dL whereas, mean among Acute Ischemic Stroke patients was 7.17 mg/dl and the difference was statistically significant with p < 0.0001. Odds ratio in our study was 6.531 with 95% CI for OR inferring that any person with abnormal uric acid level has 6.531 times more chances (OR= 6.531 with p < 0.0001) of suffering from Acute Ischemic Stroke as compared to any person with normal uric acid level. Conclusion: Our study suggests that increased risk of Acute Ischemic stroke in patients with Hyperuricemia compared to patients with normal uric acid levels. There are medications available to reduce uric acid levels, which should be made use, to reduce the risk of Acute Ischemic stroke in patients with Hyperuricemia. However further studies in larger population and study using urate lowering agents need to be performed to establish the role of urate lowering agents in reducing risk of stroke.