Disulfiram is widely prescribed to discourage alcoholics from drinking alcohol. The effectiveness of oral disulfiram as a treatment for alcoholism is severely limited due to its poor bioavailability and poor patient compliance. To minimize the failure of the orally administered drug, efforts have been made to prepare alternative dosage form of subcutaneously implantable disulfiram pellets or tablets. In the present study an attempt has been made to design and evaluate a disulfiram implant using plain drug. It is known that variation in surface area and compression force used in pellet manufacture affects their densities or hardness. The disulfiram implants have been formulated by direct compression and the effect of surface area andtwo different method (S2-550lb/Cm2, S6-1100lb/Cm2, S10-1650lb/Cm2&S14-2200lb/cm2 with 9.98mm die & punch set) and (S3-550lb/Cm2, S7-1100lb/Cm2, S11-1650lb/Cm2& S15-2200lb/cm2 with 7.98mm die & punch set) were studied on in-vitro release of implantable disulfiram pellets. The release kinetic mechanism from all the formulation was found to be zero order. Two-way ANOVA & Tukey's multiple comparison test shows the release rate constants of formulation (S2, S6, S10& S14)&(S3, S7, S11&S15) obtained by two different methods i.e., (VM & RFM) are significantly different thus the effect of two different method & effect of surface area for all formulations is significant with p value <0.0001 ****