Introduction: Seizures are one of the most common causes of neurological dysfunction in infants, which increases the risk in the first month of life. It is often associated with an increased risk of death and tragic consequences, including cerebral palsy, mental disorders and epilepsy. At present, the epidemiology of seizures in infants is not well understood and the incidence of seizures has been reported in very different countries. In some studies in Iran, the most common cause of seizures in hospitalized infants were HIE as well as idiopathic causes. The aim of this study was to determine the etiology of seizures in neonates admitted to the NICU of Abuzar Hospital in Ahvaz. Materials and methods: A retrospective descriptive cross-sectional study was performed on neonates admitted to the intensive care unit and neonatal ward of Abuzar Hospital in Ahvaz in 2009 for a period of 6 months starting from January 1, 2017. Sampling was done by census and the sample size included all cases of seizures in infants under 28 days of hospitalization in Abuzar Hospital during the study period. The file information was removed from the system, then the files were studied and reviewed