Modern management of stroke includes rapid assessment, protocol wise approach, thrombolysis for acute ischemic stroke, early specialist management and appropriate monitoring. The aim of present study is to assess the clinical outcome and improvement in quality of life of patients undergoing intravenous thrombolysis for acute ischemic stroke in tertiary care center. Material and Methods: Present study was single-center, prospective, descriptive study, conducted in patients of age 19-80 years, either gender, admitted as diagnosed case of acute ischemic stroke, underwent thrombolysis. Results: In present study, among 30 patients, majority were from 51-60 years age group (43.3 %), male patients were 63.33 %. Majority presented within 3 hours (76.67 %), had multiple risk factors (56.67 %), blood pressure at the time of admission < 185/110 mm Hg (90 %), did not required intravenous anti-hypertensives for acute control of blood pressure (83.33 %) & had normal capillary blood glucose levels at the time of presentation (63.33 %). The NIHSS score at the time of admission was in the range of 10-22 in majority of cases (76.67 %) as compared to score in range of 5-9 (23.33 %), mean score at presentation was 12.60 ± 4.17. After 24 hrs of admission the NIHSS score was in the range of 5-9 in majority cases (70 %) as compared to score in range of 10-22 (30 %), mean score was 7.83 ± 5.299. The primary outcome (i.e.) reduction of NIHSS by 4 points from the initial score is present in 60% of the study population. Conclusion: Use of intravenous thrombolysis in patients presenting with acute ischemic stroke within the window period of 4.5 hours is beneficial for the patient, and there is a great improvement in quality of life which is assessed after 3 months