Background: Respiratory distress is one of the commonest disorders of new-born and associated with most important causes of neonatal morbidity and mortality especially in premature babies. CPAP is a non-invasive method for applying a constant distending pressure level during inhalation and exhalation to support spontaneously breathing new-born with lung disease. Early CPAP reduced intubations, days on mechanical ventilation and with no increased complications. Objectives: The study was done to describe the effectiveness of Bubble CPAP as a primary respiratory support in preterm and term neonates with Respiratory Distress as well as factors associated with CPAP failure in neonates. Materials and Methods: A Prospective Analytical Study was carried out on 82 neonates with Respiratory Distress admitted in NICU within first six hours of life and were managed as per NICU protocol. All enrolled neonates were observed for at-least 72 hours for outcome and development of complications. All the Variables were analysed with the help of chi-square test. Results: Out Of 82 neonates included in this study, (78%) neonates successfully weaned off from CPAP and 18 (22%) neonates who were on CPAP required mechanical ventilation. Male: Female ratio was 1.9:1, mean gestational age was 33.1 + 3.1 weeks and mean birth weight was 1.81 + 0.56 Kg observed in this study. Conclusion: Bubble Continuous Positive Airway Pressure is safe, effective, and easy to use in preterm and term neonates with Respiratory Distress. Various factors influence the outcome of a neonate on CPAP and knowledge of these factors and their role in the successful outcome helps us in early detection of risk factors and prompt action for a better outcome.