The present study was carried out to evaluate anti-inflammatory activities in Dendrobium macraei whole plant extracts. Whole plant parts were extracted with Petroleum ether, chloroform, ethyl acetate, methanol and distilled water as the escalating order of polarity. The carrageenan induced rat paw edema model evaluated the anti-inflammatory activity of hydro-methanolic extracts. At doses 100, 200 & 400 mg/kg D. macraei exhibited significant and dose-dependent effects of anti-inflammatory activity. The current study's findings validated the folkloric use of Dendrobium macraei as an anti-inflammatory. The extracts exhibited a dose-dependent reduction in paw edema volume at different doses of 100, 200 and 400 mg/kg. The methanolic hydro extract at doses 100, 200 and 400 mg/kg significantly inhibited carrageenan-induced paw edema volume at 1h, 2h and most significantly at 3h as compared to the control. The standard drug indomethacin shows marked and significant inhibition in the volume of paw edema at 3hr at the dosage of 5 mg/kg through the oral route of drug administration.