A wide specific biochemical examination of amniotic fluid was performed in 2022 at the Republican Perinatal Center on 70 pregnant women who were delivered during this time. All pregnant women were divided into 3 groups. Group I (control) – pregnant women with physiological pregnancy and without a burdened obstetric and somatic history (n=10), group II - pregnant women who underwent COVID–19 during their 2nd-trimester gestation (n=30) and group III - pregnant women who underwent COVID–19 during their 3rd-trimester gestation (n=30). Amniotic fluid sampling was performed using transabdominal amniocentesis in the period from 22 to 38 weeks of gestation. From non-specific indicators in the group of pregnant women who underwent COVID-19, there is a decrease in the level of phosphatidylcholine, sphingomyelin, phosphatidylinositol and lysolecitin, revealing unformed and immaturity of fetal lungs; decrease in the level of the lamellar body, revealing a decrease in the production and release of pulmonary surfactant and immaturity of the fetal lungs.