Objective: This study aims to explore the relationship between social isolation, social support, and psychological distress among college students. Social isolation is a potent factor to cause psychological distress among students while social support helps neutralize the psychological distress among the mass population, especially young college students. Method: Multiple scales such as MSPSS ;( Zimet et al., 1988), REVISED ULCA SCALE (Russel.D) 1996, and Kessler’s (k10) (Kessler RC.2002) scale were used and a web survey was administered in Lovely Professional University to 400 students of different department, with 214 students completing the measures in this analysis with a response rate of 53.5 %. The mean age was 22.48 years with an SD of 2.87 years, Range (18 -27 years). The results of these scales were computed to determine the social isolation, social support, and psychological distress among college students. Result: The results indicated that social isolation was significantly related to psychological distress (r = .57, p < .001). Social support was also significantly related to psychological distress (r = -.34, p < .001) and social isolation (r = -.43, p < .001). The addition of social support significantly improved the model fit (ΔR2 = .14, F (1,214) = 36.17, p < .001). The interaction term was also significant (β = -.28, p < .001), indicating that social support moderated the relationship between social isolation and psychological distress.