Blood tests provide important diagnostic information regarding many diseases. A main and important factor that interferes with the precision and accuracy of blood tests is the presence of red blood cells; however, the traditional methods of blood separation are often complicated and time-consuming. During this study, an easy but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7% - 99.9% of the plasma during a jiffy . Principles like rate of blood flow, structure of the filter trench, and therefore the relative positions of the filter trench and channel, were optimized with the assistance of microscope monitoring. Moreover, this device which is driven by an air difference uses an economical and straightforward to use heater device that makes a low-pressure environment within the microchannel within minutes. With the aforementioned advantages, this blood separation device might be another platform choice for testing and identification of the many pathologies in a person. The aim of this study is to review a novel technique SIMBAS and its methodology.