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ISSN 2063-5346
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SILICA SUPPORTED POLYPHOSPHORIC ACID CATALYZED SYNTHESIS OF SUBSTITUTED INDAZOLES

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S. V. Raut,[a]* B. K. Dhotre,[b] S. P. More,[c] A. D. Tidke[a] and Pathan Mohd Arif[a]

Abstract

A clean and straightforward methodology developed for the synthesis of substituted indazoles using silica supported polyphosphoric acid (PPA-SiO2) catalyzed condensation reaction between substituted 2-hydroxybenzaldehydes or acetophenones and hydrazine hydrate or phenylhydrazine. The reaction conditions are optimized for different solvents at different temperatures. The yield of the products improved to 88 to 90 % using silica supported polyphosphoric acid as a catalyst, which is reusable, cost-effective and straightforward to synthesize

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