Diabetes mellitus (DM) is a group of metabolic diseases characterised by hyperglycemia resulting from an absolute deficiency of insulin secretion or reduction in the biological effectiveness of insulin or both. Even though blood has always been the gold standard for diagnosing and monitoring diabetes, saliva promises to be a reliable biofluid as it transcends several of blood’s disadvantages. The limitations faced by various biological fluids like blood, tears, sweat in monitoring glucose are surpassed by using saliva. The use of salivary glucose biosensors for real-time tracking of glucose levels in saliva convenient, and can further be used for both diagnosis of diabetes and glucose monitoring. The various biosensors which have been reviewed in this article have reported excellent detection limit and sensitivity. The devices could also be used as home care devices which could provide the patient with rapid and reliable information which could be corroborated in a healthcare setting.This paper reviews the significance of salivary biosensors for clinical diagnosis and therapeutic applications with focus on the technologies and biosensing platforms that have been reported for screening for diabetes.