Background: The incidence of Autoimmune Disorder is on a steady rise and though a lot of research is going on, the mystery regarding the etiology still remains unravelled. Oral lichen planus, a lesion considered to have an autoimmune basis is frequently encountered by the dental clinician and hence a thorough knowledge of its etiology and treatment plan is vital to us. Stress is considered as a major etiologic factor in almost all autoimmune disorders and oral lichen planus being one of them, an attempt to evaluate its role is the aim of this paper presentation.