Objective: This cross-sectional study aimed to assess the contribution of skull anthropometry in the selection of complete denture teeth among a sample of 50 patients. Methods: A total of 50 patients requiring complete dentures were enrolled in this study. Standardized calipers and measuring tapes were used to obtain anthropometric measurements, including cranial width, cranial length, and facial height. Intercanthal distance, interpupillary distance, and nasal width were also measured. Denture tooth selection was based on the average measurements derived from the sample. The esthetics of the dentures and patient satisfaction were assessed using visual analog scales.