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ISSN 2063-5346
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ROLE OF RETINOIDS AND ITS NEUROPROTECTIVE IMPLICATIONS FOR ALZHEIMER’S DISEASE

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Akila P, Tamilanban T, V. Chitra
» doi: 10.31838/ecb/2023.12.s2.131

Abstract

Chemically, all retinoids, organic and conventional, are linked to vitamin A. To initiate particular signalling pathways in cells, both synthetic and natural retinoids utilise specific nuclear receptors which including retinoic X acid receptors and retinoid receptors. As in the central nervous system, retinoic acid signalling is critical. In the central nervous system, particularly in the adult brain, retinoic acid signalling pathway dysfunction results in severe pathological processes. During ordinary brain function and growth, retinoids play a vital role in neural characterization,axon outgrowth, and differentitation. Alzheimer's disease is profoundly defined by the intensification of extraneuronal amyloid plaques and intra-neurofibrillary tangles with in temporal lobes, is caused by dysfunction retinoic acid signalling, which also results in , oxidative stress, neuroinflammation, neurodegeneration,and mitochondrial dysfunction. Alzheimer's disease is the primary cause of cognitive impairment and memory lapse in the elderly.Inactive cholinergic neurotransmission causes memory problems in Alzheimer's patients. In mice, decline of spatial memory and learning is linked to retinoic acid deficiency or defect. In Alzheimer's disease, retinoids prevent the formation of chemokines and neuro - inflammatory cytokines in astrocytes and microglia. Retinoic X receptor and retinoid acid receptor stimulation reduces amyloid deposition, decrease neuronal damage, and hence prevents AD pathogenesis through mice. In this review, We present an overview of retinoid biology, with a focus on potentianeuroprotective processes which could focus on the importance of such receptor proteins in Alzheimer's disease pathogenesis

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