The main objective of this project report is to study and brief about osteoarthritis, pathogenetic role of miRNAs and association or relation of osteoarthritis with asthma and cardiovascular diseases.Osteoarthritis is a syndrome of joint pain caused by destruction or degeneration of joints and disability in an individuals, the main causes of OA includes joint injuries, obesity, aging and genetic.The current review summarises the critical role of miRNA in determining the complex gene expression patterns of OA and other diseases. Its role in the pathophysiology of OA, as well as the potential of miRNA as a biomarker and therapeutic target for OA, will be discussed and it also focuses in the relation and association of osteoarthritis with Asthma and cardiovascular diseases.