Background: a clinical illness brought on by structural along with functional abnormalities of the heart which induce a reduce in cardiac output in addition to an increase in cardiac filling pressure is Heart failure (HF). This study used global longitudinal strain (GLS) to determined systolic dysfunction in individuals with HF with preserved ejection fraction (HFpEF). Methods: The 120 participants in this prospective research were split into three groups as follows: Group A consists of 50 individuals with overt HF, 40% of whom had HF with reserved ejection fraction (HFrEF) with a left ventricular ejection fraction (LVEF) below 40%. Group B consists of 50 individuals with signs or symptoms of HF, ejection fraction (EF) greater than 50%, left ventricular mass index (LVMI) of 115 g/m2 for men and 95 g/m2 for women, left atrial volume index (LAVI) of 34 mL/m2, as well as E/é, in accordance with criteria of European Society of Cardiology (ESC), with mean é lateral and septal wall of 9 cm/s (HFpEF). Group C (control group) comprised of 20 individuals with risk factors for HF who had moderate dyspnea or unusual chest pain and had LVEF > 50%, E/é below 8, and no structural abnormalities. Results: A statistically substantial variation was existed among the three groups as regard Echo left ventricular end-systolic volume (LVESV), Echo left ventricular end‐diastolic volume (LVEDV), A wave, Average Ee, Estimated Pulmonary arterial systolic pressure (PASP) and GLS. A high negative association was existed among GLS and Simpson EF in HFrEF, HFpEF groups. A moderate negative association was existed among GLS and Simpson EF in Control group. Conclusions: In individuals with manifestations of HF and normal LVEF, GLS may be regarded as a crucial marker for the identification of left ventricular systolic dysfunction