This study was amid to investigate the protective role of Frankincense (F) on Adenine (AD)- induced nephrotoxicity on the serum concentrations of urea and creatinine, malondialdehyde (MDA) with superoxide dismutase (SOD), besides histological and histochemical changes in the kidney of male albino rats. Twenty-four adult male albino rats were assigned randomly in to four groups (n=6 of each): Group 1 (Control) take only normal saline (0.9% NaCl), Group 2 (AD group 150 mg/kg b.w.), Group3 (AD +F 10% w/v), Group 4 (AD +F 20% w/v). The treatment was given daily via gavage for 30 days. AD group showed a significant elevation of serum urea, creatinine, and MDA while reduced SOD in comparison with the control group. Kidney sections of rats treated with AD group showed dilation of bowman’s capsule space, segmentation, degeneration of glomerulus and there was hemorrhage, necrosis, hyperplasia with crystallization, and proteinaceous remnant in some uriniferous tubules. Histochemical, AD group caused fibrosis area of kidney tissue and carbohydrates. On the other hand, both groups of Frankincense in combination with AD revealed a significant reduction in the serum urea, creatinine, and in MDA level with increase in SOD level. In conclusion, these results suggest that Frankincense have a noticeable protective and antioxidant effect against AD renal toxicity.