The aim of the research was to determine the therapeutic role of cyclosporine and azacitidine in the treatment of aplastic anemia induced by benzene in rats. The experiment was performed in 30 rats divided into five groups as C-: negative control group, C+: positive control group (benzene 1940 mg/kg), CsA: received cyclosporine at dose of 5.86 mg/kg, Aza: received azacitidine at dose of 5.75 mg/kg and combination-treated group: received combination of cyclosporine and azacitidine at dose 3.68 mg/kg for each drug. Then body weight, red cell indices, total BM cell count, total protein and histopathology for BM and hepatic tissues were measured. In conclusion, there are a good role of both cyclosporine and azacitidine alone and in combination therapy in the treatment of induced aplastic anemia.