Creatine is a very important compound for heart contraction and energy metabolism in our body. It has been proven in many pieces of research that Creatine supplementation (throughout the paper, only supplementation with creatine monohydrate will be reviewed, as this is by far the most used and best-known way of supplementing creatine) increases creatine level in the body and promote a healthy and safe heart. In heart failure, the expression of the creatine transporter is low and phosphocreatine fails to prevent ATP exhaustion because creatine and phosphocreatine content decrease. According to the research data available about creatine at this time, creatinesupplementation is very effective for heart failure patients because it helps to increase muscle strength and endurance of the heart. Creatine hasenergy-boosting properties which is why it is the strongest favorable organic compound to treat heart ischemia because heart ischemia is the condition in which the heart either reduces or loses the ability to synthesize ATP. Creatine has antitumor and anti-cancer properties. It works to prevent tumor and cancer growth by enhancing antitumor and anti-cancer activity in the body, so it is not only good for cardiac health but also beneficial for cancer patients. In this review paper, the available knowledge related to creatine and creatine supplementation has been collected and summarized so far and explores its heart health-related beneficial effects.