Botulinum toxin (BTX) commonly known as Botox, is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. Initially recognized for its therapeutic potential in treating conditions like strabismus and blepharospasm. Botox has been FDA-approved for various medical applications since its introduction. Its utility extends beyond traditional medical treatments to diverse dental procedures, including the management of temporomandibular disorders (TMD), bruxism, and clenching. Additionally, Botox has gained popularity in cosmetic dentistry for enhancing facial aesthetics by addressing issues such as wrinkles, gummy smiles, and black triangles. The toxin works by inhibiting acetylcholine release thereby reducing muscle contraction and glandular secretion. This minimally invasive treatment modality offers promising results with minimal trauma and discomfort for patients. As dental treatment options expand the application of botulinum toxin in dentistry provides a versatile, safe, and effective alternative for both aesthetic and functional dental conditions. Dental professionals with their detailed knowledge of facial anatomy are well-positioned to incorporate Botox into their practice offering innovative solutions for refractory or traditionally invasive conditions.