Background: Occupational contact dermatitis is one of the most common occupational skin diseases, caused by prolonged contact with irritants or allergens in the workplace. Some factors which play an important role in the development of occupational contact dermatitis can be host factors and external environmental factors (use of chemicals and wet working conditions). Objective: To determine the risk factors for contact dermatitis in tofu factory workers in Medan. Subjects and Methods: This study was an observational analytic study using a cross-sectional method involving 42 subjects. Multivariate analysis was carried out in order to find out more than one independent variables that have an effect on the dependent variable. Results: The proportion of contact dermatitis in tofu factory workers was 30 subjects (71,4%) and 12 subjects (28,6%) was non-contact dermatitis. Subjects majority by the age group of 26–35 years (42,8%), working experience of more than 3 years (57,1%), contact duration ≥2 hours (100%), the most location was hands (71,4%), part of work was cooking (61,9%), no history of atopy (59,5%), and incomplete use of personal protective equipment (100%). Part of work in cooking section has a significant effect on the incidence of contact dermatitis. Conclusion: The risk factor which has a significant effect on the incidence of contact dermatitis in tofu factory workers in Medan is part of work in cooking section.