Objective: Aim of current study was to determine the frequency of right ventricular dysfunction and its associated factors in patients after cardiac surgery. Study Design: Cohort study Place and Duration: The design of this study was a cohort study design and this study was conducted in Armed forces Instituted of cardiology / National Institute of Heart Diseases. Methods: Total 314 patients were included after post-operative cardiac surgery. Treatment and diagnosis of RV dysfunction were implemented. Clinical relevance was the only criterion for RV dysfunction consideration: the presence of hemodynamic instability necessitating catecholamine support and the use of sildenafil to relay inhaled nitric oxide. SPSS 22.0 was used to analyze all data. Results: There were 190 (60.5%) males and 124 (39.5%) females among all patients. Patients mean age was 67.8±7.17 years. Frequency of RV dysfunction was found in 18 (5.7%) cases. Very severe outcomes were observed among cases of RV dysfunction included prolong ICU stay, mortality, reintubation and stroke. Patients of RV dysfunction had mean age 70.5±3.12 years, mostly were females with more history of atrial fibrillation and greater euro score II. Conclusion: The rate of patients experiencing clinically severe RV dysfunction after surgery was 5.7% in this cohort analysis. Death, strokes, reintubation, and extended stays in the critical care unit were among the worst unfavorable events linked to RV dysfunction.