Schiff bases are very important compounds synthesized from the condensation reaction of primary amines and carbonyl compounds having a wide application in industrial area and also have biological activities i.e., antibacterial, anti-inflammatory, antifungal, antimalarial, antiviral, anticancer properties. There are a lot of journals published the various applications of these compounds in past few decades. The various spectroscopical and elemental studies have done to show the binding of their metal complexes with DNA and various clinical applications and found some unbelievable results of these complexes in clinical field, i.e., cis platin and their derivatives like carbo platin have many side-effects with their anti-cancer treatment but metal complexes of Schiff bases reduce these side-effects and also increase their activity.