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ISSN 2063-5346
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RESPONSE OF NEW GALLIC ACID DERIVATIVE AND PUNICA GRANATUM SEEDS EXTRACT AGAINST MENINGITIS TRIGGERING PATHOGENS

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Velmurugan Chinnasamy, Rajul Gupta, Pradeep Kumar Sharma
» doi: 10.31838/ecb/2023.12.s1-B.180

Abstract

Some atypical bacteria may cause upper respiratory tract infection and may result in meningitis by traveling via bloodstream to brain. Facts over S. aureus and E. coli to cause meningitis, antimicrobial potential of Punica granatum plant and gallic acid intended current study to compare the antibacterial response of new gallic acid derivative (GAD) and Punica granatum seeds extract (PGSE) against meningitis triggering bacteria (MTB). Present study involved synthesis of GAD and preparation of PGSE. The GAD was characterized using ATRIR, 1H-NMR and Mass spectrometric data. Both PGSE and GAD were tested for inhibitory potential against MTB, namely: S. aureus and E. coli. Amid both, the GAD exhibited high inhibitory potential against MTB, when compared with PGSE. Based on the results present study concludes that GAD possess high inhibition potential against MTB and recommends that GAD should be further tested to support its clinical significance.

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