Introduction:-Menopause is the natural step in the process of aging. Women face various physiological, psychological and sociological changes which impair the quality of life during menopause. The risk of nutritional disturbances, particularly trace elements and vitamin deficiencies are high during menopause. Aims & objectives:- To compare the Serum level of Oxidative Stress Marker along with the level of total antioxidant status in Pre & Post-menopausal Women. Observation and Result:-The Oxidative stress marker (MDA) level was significantly lower (1.5±0.46), (p-value-0.0001) in Premenopausal women than that of Postmenopausal women (2.84±0.69). But Antioxidant status level was found to be significantly higher (15.1±2.4) in Premenopausal women than that of Postmenopausal women (10.53±2.54). Conclusion:-Menopause is associated with oxidative stress which predisposes to the development of various diseases like osteoporosis, depression, diabetes, and hypertension. Dietary, management, antioxidant supplementation, and moderate physical activity would help to prevent diseases related to menopause