Antipsychotic drug quetiapine is frequently prescribed for the treatment of psychiatric disorders. It is an atypical antipsychotic drug that, because of its sedative qualities, is also used outside of its approved uses to treat anxiety and insomnia. Peripheral edema may occur more frequently than indicated in clinical trials, despite having a relatively low incidence of side effects. Peripheral edema caused by additional second-generation antipsychotics has the potential to affect patient adherence to therapy. Another side effect of quetiapine is oral ulceration, while transient lingual papillitis is a less common side effect. Small bumps that form on the tongue as a result of this condition can be uncomfortable and make eating and speaking challenging. However, it quickly subsided after the medication was stopped. It is crucial for medical professionals to be aware of quetiapine's potential side effects and to inform their patients about what to anticipate while taking the drug. Patient compliance and treatment outcomes as a whole may benefit from this.