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ISSN 2063-5346
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PROTECTIVE ROLE OF ALHAGI GRAECORUM BOISS ON INTESTINAL FUNCTION AGAINST ASPIRIN IN ADULT MALE RABBITS

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Sawsan Kadhim Mashi, Majida A. AL-Qaiym
» doi: 10.31838/ecb/2023.12.s2.231

Abstract

The effect of Alhagi graecorum Boiss on intestinal function and morphological changes in response to aspirin-induced intestinal damage was investigated in this study on male rabbits. The experiment employed twenty healthy adult male rabbits. The animals were separated into four groups. at random (5 rabbits per group) and treated for 42 days as the following: a control group (C): Rabbits were allowed free access to drinking water, T1 group: Animals received (10 mg /kg b.w) of aspirin orally , T2 group: were administered 400 mg/ kg b.w ethanolic extract of Alhagi graecorum and 10 mg/kg of aspirin orally , T3 group: animals were given 400 mg/ kg b.w alcoholic extract of Alhagi graecorum orally. After 42 days of the experiment, D-xylose absorption test was performed for all animals. Blood samples and intestinal segments were collected at the end of the experiment. The results shown that oral intubation of Aspirin for 42 days caused intestinal dysfunction manifested by a substantial decrease (P<0.05) in D-xylose in the T1group, whereas the animals given Alhagi graecorum showed a considerable elevation (P<0.05) in the levels of D-xylose. The histomorphological examination revealed significant reduction(P<0.05) in goblet cells size and density, villi high, villi thickness, enterocyte and crypt depth in T1 group compared to other groups while all these parameters considerably increased (P<0.05) in animals received Alhagi graecorum. Furthermore animals received aspirin had significant (P<0.05) reduction in food intake and body weight whereas animal received alhagi graecorum exhibited substantial (P<0.05) increase in both food intake and body weight. It can be concluded that intestinal deleterious changes induced by aspirin can be prevented by Alhagi graecorum extract.

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