Klebsiella pneumoniae is a Gram-negative, non-enveloped bacterium in the family Enterobacteriaceae. This organism is one of the most common opportunistic bacteria associated with hospital-acquired and community-acquired infections, especially in immuno-compromised patients causing urinary tract, respiratory tract, and lower biliary tract infections. , soft tissue, blood, surgical wound and liver. All penicillins and cephalosporins, and monobactams like aztreonam, are resistance to extended-spectrum -lactamases (ESBLs). Carbapenemases are beta-lactamases capable of hydrolyzing penicillins, cephalosporins, carbapenems and monobactams, and are in the Ambler group A, D . These bacteria-producing enzymes cause serious infections in which beta-lactams are in effective . Drug resistance in developing countries like India has several reasons including over use of antibiotics, easy availability of antibiotics