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ISSN 2063-5346
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PREPARE AND EVALUATE A FORMULA TO OVERCOME LIMITATION OF BETAMETHOSNE TO PENETRATE THROUGH TOPICAL ADMINISTRATION: EMULGEL

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Nitin Bhatt1*, Sunil Jawla2 , Vikram Singh3
» doi: 10.48047/ecb/2023.12.si5a.0168

Abstract

The aim of the present study was to formulate a formula of Betamethosne as emulgel. The model drug Betamethosne is a pharmacologically anti-fungal activity. Betamethosne has tendency to bind intracellular glucocorticoid receptor which then bind to DNA of infecting micro and ultimately effect gene expression. The selected hydrophobic drug were difficult to administer through trans-dermal route but through this modified emulgel approach provide a double layered control on drug release. For gel preparation Carbapol 934 and Hydroxypropyl methylcellulose K15M were used. Working medium temperature, mixing speed, mixing time and pH were studied as formulation working variables. Formulation code E6ABc3 was found best formulation on the basis of drug release pattern, stability and Ostwald ripening. Possible way of drug molecule transportation was studied with the help of SEM study and found that there was no sign of keratolysis.

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