The drug benzoyl peroxide (BPO) is the main drug used for mild to moderate acne due to its effectiveness 8. It is an antimicrobial drug which kills the anaerobic bacteria Propionibacterium acne, the bacteria involved in pathogenesis of disease. It is sebostatic, comedolytic and anti-inflammatory agent. But low water solubility and limited skin permeation upon topical application requires high amount of drug for desired action which leads to many side effects such as redness, skin irritation, dryness oedema and skin peeling 9. These may be due to keratolytic property and high concentration used of benzoyl peroxide. The present study focus on Preparation, Evaluation and Optimization of Film Forming Gel of Benzoyl Peroxide. Benzoyl Peroxide Film Forming Gel of Benzoyl Peroxide was prepared using dispersion method. The main objective of the study is to preparing Benzoyl Peroxide in the form of FFG which may give sustained release action by using Eudragit LR100 and HPMC in combination. Experimental design was obtained using design expert software and by using 3 by 2 factorial design method in which the effect of concentration of Eudragit LR100 and concentration of HPMC 4000 on Film Forming gel was studied. 9 batches of film forming gel of benzoyl peroxide war prepared and evaluated for various parameters. By using Optimization Technique, Batch B8 was selected as the optimize batch in which 12% of Eudragit LR100 and 1 % of HPMC 4000 was used. The optimized batch was evaluated for skin irritation test and stability test. Skin irritation test was carried out and NO presence of erythema or oedema were seen on the animals after 14 days of application of Film Forming Gel. Stability test was also carried out and Film Forming gel was found to be stability for 60 days after preparation