We developed gastrointestinal mucoadhesive patches containing 6-mercaptopurine and pectin to prolong the release and improve the absorption of the drug. It was observed that all formulations prepared for the fabrication of gastrointestinal mucoadhesive patches were smooth, translucent, and flexible. Throughout the formulations, uniform weights and thicknesses were observed. The following parameters were also evaluated on these Gastrointestinal Mucoadhesive Patches: pH, folding endurance, swelling percentage (%S), and in vitro disintegration time. Gastrointestinal Mucoadhesive Patches have shown enhanced release profiles in vitro compared to pure drugs, and the release patterns are pH-dependent. To conclude, solvent cast technology is an efficient method for delivering 6-mercaptopurine to the gastrointestinal tract via gastrointestinal mucoadhesive patches.