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ISSN 2063-5346
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PREPARATION AND CHARACTERIZATION OF SOME NEW OXAZEPINE COMPOUNDS

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Natiq G. Ahmed[a]* and Hussein Y. Al-Hashimi
» doi: 10.17628/ECB.2016.5.88

Abstract

The ketonic compound (1) is synthesized from equal moles of morpholine, 4-nitrobenzaldehyde, and 3-nitro acetophenone. Schiff base compounds (2)-(4), prepared by reacting (1) with different aromatic amines (4-aminoantipyrine, p-phenylenediamine, 2-aminopyridine), contain a set of one or more of azomethine (-C=N-) groups that have been used in the preparation of many heterocyclic compounds, which when reacted with maleic anhydride give 1,3-oxazepine compounds (a ring with seven atoms) (5)-(7), and seven membered ring benzo[1,3]oxazepine compounds (8)-(10) are obtained by reaction with phthalic anhydride. The synthesized compounds are identified using physical (melting points, colour change, thin layer chromatography) and spectral methods such as IR, UV, and NMR spectra). The biological effectiveness of some of the prepared compounds is measured.

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