The outcomes of this research showcase the predictive analysis of the behaviour of Newtonian and non-Newtonian fluids while being heated during their flow through a tube with ellipsoidal dimples, employing numerical simulations. The findings have significant implications for manufacturers who rely on constant viscosity values for heat exchanger design or lack information about viscosity variations during processing. By changing the elliptical dimple angles to 0°, 45°, and 90° and using cross-combined configurations, the research looked at how heat is transmitted in tube sections with Reynolds numbers ranging from 3000 to 8000. Additionally, pitch lengths (PL) of 10– 30 mm were tested while keeping the heat flux constant at 20000 w/m2 and maintaining a wall thickness of 1 mm. Results showed that cross-combined dimple tubes improved heat transfer by an average of 25.6%. The highest Nusselt number was achieved using a tube with an 8 mm diameter ratio, a twist angle of 90°, and a PL of 10 mm, specifically at Re of 8000. On the other hand, the tube with the 8 mm dimple diameter (Dd), cross-combined with a 10 mm PL, notably at a Re of 3000, was found to have the lowest friction factor (f).