Background: Skin, the largest organ of living organisms, tends to separate the external surface which covers about 15% of the body weight of rats. Post-mortem diagnosis of hypothermia is challenging, therefore in this study we detected the histopathological changes that occur in adult albino rats. When compared to human skin, rat skin shows change in adipose tissue, nerves, mesodermal origin, etc after post-mortem analysis. Rats are efficiently used as models to assess nutritional deficiencies, aging, etc. Aim: The aim of our study is to assess the histological changes seen in the skin and epithelial tissues seen in submerged wistar rats during post-mortem Method: Albino strain of wistar rats weighing 180-210g were used in this study. The rats were divided into two groups. Group one contains 4 wistar rats and Group two contains 2 wistar rats. Group one wistar rats were killed by submerging them into water. Group two wistar rats are clinically sacrificed as normally done for any study. After a time duration of 72hrs, postmortem analysis is done where the skin and epithelial tissues are taken into account. Routine H and E stainings are performed and IHC staining was also done. Results: Under histopathological analysis, necrosis of muscle and collagen decomposition is seen in various levels, necrosis of skin are seen and decreased vessel wall thickness was observed (SMA).The detachment of hair or hair sloughing and black discolouration of the ruptured skin was observed and layers of the epithelium are difficult to distinguish completely. Conclusion: From our study we have observed changes like sloughing of hair, black discoloration of ruptured skin and also coagulation necrosis has been observed in the epithelial tissues during post-mortem analysis.