There is a trend on the increase in the use of cosmetics and whitening creams containing hazardous substances such as hydroquinone and mercury. This trend was caused by women's demands to appear beautiful and attractive as well as its great financial potential. Unethical producers of cosmetics and whitening creams utilize this trend by inserting products with hazardous substances such as hydroquinone and mercury. These two hazardous substances impose health risks. Hydroquinone brings the risks of exogenous ochronotic, cataract, colloid milia pigments, sclera, nail pigmentation, loss of skin elasticity, and impaired skin healing. The use of hydroquinone for years may also cause symptoms of dark spots, allergies, and skin irritation. High dosages can cause permanent damage to the brain, cancer, kidney disease, and fetus development disorders. Mercury exposure may cause vomiting, diarrhea, and lung damage. It is also a carcinogenic substance. Policies on handling cosmetics containing hydroquinone and mercury hazardous substances need to be intensified to prevent more victims.