Drug distribution depends on bioavailability, notably for phyto-constituents, which have broad therapeutic potential but low bioavailability. Phospholipid complex technology may improve phyto-constituent bioavailability and medicinal efficacy. This review discusses phyto-constituent bioavailability issues and proposes phospholipid complex technology as a solution. Phytochemicals have great medicinal promise, but their low bioavailability makes them difficult to use