The growing demand of human beings for an improved healthy life and increased longevity has led them to explore and utilize nutritious foods with plentiful sources of bioactive compounds and other nutraceuticals. Among these renowned natural resources, seaweeds are considered as one of the most priceless natural resources for macronutrients such as carbohydrates, proteins, and lipids, micronutrients such as vitamins and minerals, and other significant bioactive substances for animal and human health. Seaweeds are eukaryotic organisms typically found and live in salty water. Traditionally, they are consumed as food, fodder, fertilizer and as a source of medicine since ancient times. Macroalgae are marine photosynthetic organisms or marine seaweeds belonging to the domain Eukarya and the kingdoms Plantae. These macroalgae are classified into 3 main classes i.e. red algae (Rhodophytes), brown algae (Phaeophytes), and green algae (Chlorophytes). The red seaweed (Rhodophyta) is one of the major phyla of macroalgae, typically classified as non-vascular plants from the Primoplantae clade and contains approximately 6100 species. Palmaria palmata (L.) O. Kuntze is commonly known as dulse or sol. commonly grows on the larger marine plants such as Laminaria spp. or on rocks in the littoral and sub-littoral zones of the north Atlantic seacoasts. It is a well-known red seaweed among the species of (Rhodophyta). This systematic review is designed to provide a deep knowledge and information about famous red seaweed Palmaria palmata with special emphasis on its phytochemical characteristics and biomedical uses.