Adina cordifolia, a member of the Rubiaceae family, was investigated for its hepatoprotective properties against Wister rats that had experienced liver damage brought on by ethanol (AEAC) and its aqueous extract (AQEAC). It was discovered that AEAC and AQEAC, at a dosage of 500 mg/kg body weight, had hepatoprotective effects by dramatically reducing the levels of serum SGPT, SGOT, alkaline phosphate, and total bilirubin as well as significantly raising the levels of total protein. Histopathological examinations of liver tissue provided further evidence for the hepatoprotective action. Since blood samples from rats given ethanol treatment showed a significant increase in serum enzyme activities, reflecting liver damage brought on by ethanol, and blood samples from animals given AEAC and AQEAC showed a significant decrease in serum markers, indicating that hepatic cells were protected from ethanol-induced hepatocellular injury. Similar to the effects of the common medication silymarin, AEAC and AQEAC were effective.