Pyrimidine skeleton, a diverse skeleton with the various applications in medicinal field had beenstudied and reviewed since previous era. This scaffold had given a great revolution in field of pharmaceutical sciences. Many anti-cancer, anti-viral, anti-microbial, anti-inflammatoryagents had been provided by this scaffold utilization. Its fused scaffold had brought a great revolution in the field as a result had become a scaffold with multi target ability. This review basically comprises of various compound synthesized using this scaffold against the various diseases majorly from year 2016-2019.It also gives an insight into the structural moieties’substituent thathelps them to attain the potency of inhibiting the various targets