Individuals with systemic conditions are at more risk of dental disease,have a greater prevalence and incidence of periodontal diseases. The aim of the study is to assess the periodontal status in medically compromised patients. It is a retrospective study regarding the association of periodontal disease status with systemic conditions in patients visiting a university dental hospital in Chennai in between June 2019 March 2020, the data of 86000 patients were reviewed and analysed. It included parameters - age, gender, periodontal disease status, systemic conditions. Chi-square test was used to detect the significance between the periodontal disease status and systemic conditions. In this study we observed that patients who were medically compromised were more prone to periodontal diseases.The most affected age group with systemic conditions and periodontal diseases was 46-90 years (74%). Males were found to be more affected (56%). Patients with diabetes and hypertension were more prone to periodontal diseases when compared with the other systemic conditions. Within the limits of this study, it is concluded that patients who were medically compromised were more prone to periodontal diseases. Patients with diabetes and hypertension were more prone to periodontal diseases when compared with the other systemic conditions.