Rapid industrialization is adversely impacting the environment globally. Pollution by inappropriate management of industrial wastewater is one of the major environmental problems in India as well as in developing countries, especially with growing small scale industrial sector in the countries. The pharmaceutical industry produces effluent having high concentration of dissolved solids and organics. The present study is a case study in a zero discharge plant installed in a pharmaceutical industry for treatment of wastewater to carryout to improve the performance of Zero Liquid Discharge System. 1. Wastewater treatment by Stripper Column and its performance in removing organics from Wastewater. 2. Adding additional stripper in series to improve the performance for the removal of organics and moisture content from wastewater 3. Pilot plant studies with Tubular Filter Membrane for the removal of suspended solids from bio treated water for improving the performance of Reverse Osmosis System. There are two streams of wastewater generation from the plant activities. 1.High TDS Stream from process and washings.2. Low TDS Stream from utilities and domestic These effluents are treated in Zero Liquid Discharge System comprises of Stripper, MEE, ATFD, Bio ETP followed by Reverse Osmosis System. The treatment system for treating High TDS effluents consists of Oil and grease trap, Equalization, Neutralization, Primary clarifier, Stripper, Multiple Effect Evaporator followed by Agitated Thin Film Dryer (ATFD). The concentration generated from MEE is fed to ATFD to get dry Salt. These Salts are disposed to TSDF which is an authorized agency for disposal of hazardous waste In the present study, modifications in the stripping system & pilot plant studies with tubular filter membrane for bio treated water are carried and results are compared. Additional Stripper is added in series to the existing stripper to improve the performance of the existing stripper column with respect to MC of top distillate and also in removal of organics from wastewater. 1. It is found that the stripper top distillate generated is enriched with organics with an average moisture content of 9% .2. Stripper Top Distillate COD is 84.76% (8,47, 664 mg/l). A pilot plant study was carried on biotreated water (which is further treated in Reverse Osmosis) with Tubular Filter Membrane Process. It is observed that Tubular Filter Membrane is more effective in removal of suspended solids (91-95%). The advantages due to removal of suspended solids by Tubular filter membrane are 1. Bio fouling of Ro Membranes is reduced. 2. RO System efficiency is improved 3. RO System -CIP cycles are reduced.