The fight against cardiovascular pathology is one of the paramount problems of medicine due to the significant spread of these diseases, often leading to premature old age and lethal outcomes. In this connection, we have undertaken a study of the influence of the unfavorable factor, high ambient air temperature, on functional shifts in the heart muscles. Objective: Revealing the mechanism and regularities of the impact of unfavorable air temperature on the parameters of carbohydrate-energetic processes in the heart and activation of the adaptation process by the introduction of biologically active substances.