Introduction: - Pemphigus vulgaris (PV) is a potentially fatal autoimmune, intraepithelial acantholytic disease characterized by flaccid blisters and erosions of the skin and mucous membrane. Patient compliance is the extent to which the actual behavior of the patient coincides with medical advice and instructions; it may be complete, partial, erratic, nil, or there may be over-compliance. The aim of the study was to determine patient compliance in treatment of pemphigus vulgaris and improvement in quality of life. Materials and methods: - A retrospective study was conducted on patients who visited the Oral Medicine Department from 2019 - 2022. Patients who are histologically diagnosed with Pemphigus vulgaris were included. Results: - Out of 38 patients, 6 patients did not report for follow-ups, 16 patients were irregular for follow-ups and partial resolution of the lesion was observed and 16 patients reported for regular follow-ups and their lesions status had completely healed. Conclusion: - The goal of management of pemphigus vulgaris is to reduce the severity of lesions, prevent fresh vesicles and ulcers forming and achieve complete remission and control.